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KMID : 0389420100180020081
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Korean Journal of Stress Research
2010 Volume.18 No. 2 p.81 ~ p.86
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Stress-induced Neuroimmuno Alterations in the Rat
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Lee Hyun-Ju
Kim Kyung-Soo
Shim In-Sop
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Abstract
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Severe stress such as immobilization (IMO) affects the central nervous system, the endocrine system and the immune system that interact each other. IMO-induced responses are activation of hypothalamic-pituitary-adrenal (HPA) axis and production of inflammatory cytokine. The locus coeruleus (LC), which is known to play a role in modulating stress response, innervates the paraventricular neucleus (PVN) of the hypothalamus thereby activating HPA-axis. In this study, IMO-induced alterations of HPA-axis hormones and interleukin-4 (IL-4) were investigated. The final hormone of HPA-axis, corticosterone (CORT) was injected to clarify the interaction of the HPA-axis and IL-4 in the stress response. Single exposure of stress resulted in an increase of corticotrophin-releasing factor expression in the PVN, adrenocorticotropin hormone and CORT levels in the serum. Increased expressions of HPA-axis hormones in the acute stressed group were decreased in repeated stressed group. IL-4 level in the LC of the brain was decreased in both stressed group and repeated CORT injected group. These results suggest the possibility of stress-induced interplay of HPA-axis and IL-4 in the LC.
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KEYWORD
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Interleukin-4 (IL-4), Locus coeruleus, Hypothalamic-pituitary-adrenal axis (HPA-axis), Corticosterone
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